Competing Endogenous RNAs in Cervical Carcinogenesis: A New Layer of Complexity

MicroRNAs (miRNAs) regulate gene expression by binding to complementary sequences within target mRNAs. Apart from working ‘solo’, miRNAs may interact in important molecular networks such as competing endogenous RNA (ceRNA) axes. By for a limited pool of miRNAs, transcripts long noncoding RNAs (lncRNAs) and mRNAs can each other, fine-tuning expression. Several ceRNA led different lncRNAs—described here lncRNA-mediated ceRNAs—seem play essential roles cervical cancer (CC). conducting an extensive search, we summarized involved CC, highlighting the major impacts dynamic changes over multiple cellular processes. Through sponging distinct some lncRNAs HOTAIR, MALAT1, NEAT1, OIP5-AS1, XIST trigger crucial changes, ultimately increasing cell proliferation, migration, invasion, inhibiting apoptosis. Likewise, several seem be sponge tumor-suppressive (as miR-140-5p, miR-143-3p, miR-148a-3p, miR-206), impairing molecules exerting negative post-transcriptional regulation Curiously, code proteins PTEN, ROCK1, MAPK1, known modulate growth, apoptosis, adhesion CC. Overall, highlight functional interactions occurring cells their closely related impact on carcinogenesis.